STAT3、VEGF基因在新疆哈萨克族食管癌中的表达及其相关性研究

doi:10.3969/j.issn.1004-616x.2010.03.014

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2010, Vol. 22 ›› Issue (3): 218-220.doi: 10.3969/j.issn.1004-616x.2010.03.014

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Expression of STAT3, VEGF in esophageal carcinoma and its correlation in Xinjiang Kazaks

WANG Hong-jiang1;GUO Wen-jia2;＃;LI Hui3;PANG Zuo-liang1;CHEN Yan2;JIANG Xiao-fang3;ZHANG Jing-ping2;ZHANG Li-ping2;FAN Zhi-qin1;ZHAO Xue-xin2;LI Hui-wu3

1. Department of Thoracic Surgery, Affiliated Cancer Hospital；2. Department of Biochemistry, Pre-clinical Medicine College；3. Department of Science Research Center, Pre-clinical Medicine College, Xinjiang Medical University, Urumqi 830011, China

Received:2010-01-27 Revised:2010-03-08 Online:2010-05-30 Published:2010-05-30
Contact: LI Hui-wu

Abstract

Abstract: OBJECTIVE: To study the expressions of STAT3 and VEGF gene and to explore their roles in the process of esophageal cancer in the Kazaks. METHODS: Using RT-PCR to detect STAT3, VEGF in 30 cases of esophageal cancer tissues and their corresponding adjacent tissues. RESULTS: The positive rate of STAT3,VEGF mRNA expressions were 73.33％(22/30) and 76.67％(23/30),respectively,in the esophageal cancers, and 43.33％(13/30)in adjacent tissues. There was significant difference in the expressions of STAT3, VEGF mRNA level between tumor tissue and adjacent tissues. CONCLUSION: STAT3, VEGF gene could have important roles in carcinogenesis of esophageal cancer in the Kazaks. The combined action of STAT3 and VEGF genes could promote carcinogenesis and development of esophageal cancer.

Key words: esophageal cancer in the Kazaks, STAT3, VEGF, RT-PCR

CLC Number:

R735.1

WANG Hong-jiang, GUO Wen-jia, ＃, LI Hui, PANG Zuo-liang, CHEN Yan, JIANG Xiao-fang, ZHANG Jing-ping, ZHANG Li-ping, FAN Zhi-qin, ZHAO Xue-xin, LI Hui-wu. Expression of STAT3, VEGF in esophageal carcinoma and its correlation in Xinjiang Kazaks[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2010, 22(3): 218-220.

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Expression of STAT3, VEGF in esophageal carcinoma and its correlation in Xinjiang Kazaks

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