甘肃汉族妇女XRCC1和CCNH基因多态性与乳腺癌及乳腺良性肿瘤易感性研究

doi:10.3969/j.issn.1004-616x.2014.04.012

Abstract

Abstract:

OBJECTIVE: To study the association between XRCC1 rs25487 and CCNH rs2234942 polymorphism with the susceptibility to breast cancer and benign breast tumor in Han women in Gansu area. METHODS：Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used for the polymorphism of XRCC1，CCNH in 101 cases of breast cancer，101 benign breast tumors and 101 disease-free controls collected in Gansu. Logistic regression analysis was used for comparing the genotypes or clinical pathological characteristics with the risk of breast cancer. Chi-square test was used to compare menarche age and disease onset age with the risk of breast cancer or benign tumor. RESULTS：Logistic regression analysis showed that XRCC1 rs25487，GG genotype increased the risk of breast cancer (P=0.001，OR=6.39，95%CI：2.18－18.65). Regarding the clinicopathological immunohistochemical characteristics，the distribution of AA/AG genotype was significantly different between PR+ and PR- at XRCC1 rs25487(P=0.04，OR=0.29)，while the distribution of AG/GG genotype was significantly different in Her-2+ cases and Her-2- (P=0.008，OR=0.45). Chi-square test found that the menarche age of GG/AG genotype in XRCC1 rs25487 and GG genotype in CCNH rs2234942 was significantly different in breast cancer and benign tumor (P= 0.001， 0.043，0.049). The disease onset age of GG genotype in both XRCC1 rs25487 and CCNH rs2234942 was significantly different in breast cancer and benign tumor(P=0.019，0.048). CONCLUSION： GG genotype in XRCC1 rs25487 increased the risk of breast cancer. AA/AG genotype in XRCC1 rs25487 with PR+ and AG/GG genotype in CCNH rs2234942 with Her-2+ reduced the risk of breast cancer.

Key words: RCC1, CCNH, SNPs, breast cancer

WANG Lan，ZHU Gong-jian，MIN Jian-ping，GUO Hong-yun，YANG Sui-sheng， ZHANG Bin-ming，HU Qing-rong，YANG Kai，CHEN Xue-zhong，SU Hai-xiang. The relevance of XRCC1 and CCNH gene polymorphism to breast cancer and benign breast tumor in Han women of Gansu province[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2014.04.012.

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The relevance of XRCC1 and CCNH gene polymorphism to breast cancer and benign breast tumor in Han women of Gansu province

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