Carcinogenesis, Teratogenesis & Mutagenesis ›› 2006, Vol. 18 ›› Issue (5): 384-386.doi: 10.3969/j.issn.1004-616x.2006.05.014

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The Expression of Survivin and Bcl-2 are Associated with Nasopharyngeal Carcinoma

XIANG Qiu, ZENG Si-en, LIU Qiang-he, HE Xiao-song, HOU Qiao-yan, FAN Cai-wen,XIAO Sheng-jun, LEI Xun   

  1. Guilin Medical College, Guilin, 541004, China.)
  • Received:2006-01-18 Revised:2006-04-11 Online:2006-09-30 Published:2006-09-30
  • Contact: LEI Xun

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Abstract: BACKGROUND ＆ AIM: To study the expressions of survivin and Bcl-2 in nasopharyngeal carcinoma(NPC) and the association between their expressions and NPC. MATERIAL AND METHODS: Using immunohistochemical staining, the expressions of survivin and Bcl-2 were assessed in 68 cases of NPC and 45 cases of nasopharyngeal chronic inflammation tissues. Using RT-PCR, the expressions of survivin and Bcl-2 was measured in 24 cases of NPC and 18 cases of nasopharyngeal chronic inflammation tissues. RESULTS: Analyzed by immunohistochemical staining, the expressions of survivin and Bcl-2 were 69.1％(47/68) and 79.4％(54/68),respectively,in NPC, statistically different(P<0.01)when compared with 15.6％(7/45) and 13.3％(6/45),respectively,in nasopharyngeal chronic inflammation tissues. Analyzed by RT-PCR, the expressions of survivin and Bcl-2 were,79.2％(19/24) and 87.5％(21/24),respectively, in NPC, statistically different(P<0.01)when compared with that 22.2％(4/18) and 27.8％(5/18),respectively, in nasopharyngeal chronic inflammation tissues. CONCLUSION: The expressions of survivin and Bcl-2 might play important roles in the development of Nasopharyngeal carcinoma.

Key words: nasopharyngeal carcinoma, apoptosis, Bcl-2, survivin