邻苯二甲酸酯类物质对蚕豆根尖细胞微核率的影响

doi:10.3969/j.issn.1004-616x.2013.06.017

Abstract

Abstract:

OBJECTIVE: To study the mutagenicity of some kinds of phthalate esters. METHODS：Vicia faba root tips were exposed to different concentrations of phthalate esters including dimethyl phthalate，dibuthyl phthalate，bis (2-ethylhexyl) phthalate，diethyl phthalate and dipropyl phthalate for 24 hours. Number of micronuclei of vicia faba root tips cells was observed. RESULTS：Compared with the negative control group，while dimethyl phthalate at the concentration of 0.008，0.016，0.032 mg/L，phthalate dibutyl and phthalate dioctyl at the concentration of 0.016，0.032 mg/L，respectively，there were significant differences in micronucleus rate (P<0.05). Compared with the negative control group，there were no significant differences in micronucleus rate of phthalate diethyl exposured groups and dipropyl phthalate exposured groups (P>0.05). CONCLUSION：The present study demonstrats that dimethyl phthalate and dibutyl phthalate，dioctyl phthalate displayed genetic toxicity and low concentration of diethyl phthalate and phthalate dipropyl showed no genotoxicity.

Key words: phthalate esters, vicia faba , root tip cells, micronucleus test

DUAN Li-ju，WANG Hai-xue，GAO Liu-chuang，TANG Zhi-min，JI Zong-hui，FAN Qing-tang，CUI Liu-xin. Effect of phthalate esters on micronuclei rates in vicia faba root tip cells[J]. Carcinogenesis, Teratogenesis & Mutagenesis, doi: 10.3969/j.issn.1004-616x.2013.06.017.

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Effect of phthalate esters on micronuclei rates in vicia faba root tip cells

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