Abstract: Purpose : To study the genotoxicity of non - volatile organic chemicals in Huai river water to organism. Methods : zool of water sample was collecfed f rom Huai river source water、clarified filt ration water 、chlorinated tap water and reservoir’s water , respectively. After being adsorpted and concent rated , water samples were administ rated by gavage into mouse stomach. The mutagenicity was studied by means of micronucleus test in mouse thoracic bone - marrow polychromatic erythrocyte (PCE) and the genotoxicity by means of sperm morphologic analysis. Results : the mutagenicity and sperm deformity of some degree are induced by Huai river source water and tap water. The order of mutagenic potentiality of those samples is as follows : chlouinated tap water > reservoir’s water > source water > clarifying fillration water. Conclusion : The source water is contaminated by organic mutagens. Using coagulation and precipitation , genotoxicity of source water is decreased because of the removal of some mutagenic organic chemicals. Addifionally chlorination can increase the genotoxicity of tap water.

Key words: Huai river water, organic chemicals, genotoxicity, mice