Abstract: Purpose and Methods : This paper studied the genotoxic effect s of V2O5 in male mouse germ cells using st ructural chromosome aberrations and microncleus method. Male mice were int raperitoneally injected once every day with doses of 0. 71mg/ kg、2. 13mg/ kg、6. 40mg/ kg of V2O5 for 5 days. Results : In metaphase2I spermatocytes , the f requencies of st ructfural chromosome aberration were significantly increased , which was 1. 4 % ,2. 6 % , 4. 2 % , respectively V2O5 significantly increased the f requencies of micronucleated early spermatids ,which was 2. 8 ‰, 4. 00 ‰, 7. 8 ‰, respectively. Conclusion : The result s indicated that V2O5 is mutagenic activity in male mouse germ cells.

Key words: vanadium pentoxide, male mouse germ cells, micronucleus, chromosome aberrations