癌变·畸变·突变 ›› 2001, Vol. 13 ›› Issue (1): 10-012.doi: 10.3969/j.issn.1004-616x.2001.01.004

• 论著 • 上一篇    下一篇

上海“本地人”正常人群GSTT1 和GSTM1 基因型多态性研究

林国芳1, 马晴雯1, 查永林2, 娄克俭2, 陈纪刚3, 沈建华1   

  1. 11 中国科学院上海昆虫所中德毒理学实验室(DCL T), 上海　200025; 21 上海市青浦县精神卫生中心, 上海　201700; 31 上海市疾病预防控制中心, 上海　200336
  • 收稿日期:2000-04-05 修回日期:2000-05-24 出版日期:2001-01-30 发布日期:2001-01-30
  • 通讯作者: 沈建华

GENETIC POLYMORPHISM OF GLUTATHIONE S- TRANSFERASE T1 AND M1 IN SHANGHAI“INDIGENE”POPULATION

LIN Guo - fang1, MA Qing - wen1, ZHA Yong - lin2, LOU Ke - jian2, CHEN Ji - gang3, SHEN Jian - hua1   

  1. 1. Sino - German Laboratory of Toxicology ( DCLT), Shanghai Institute of Entomology, Chinese Academy of Sciences, Shanghai 200025, China; 2. County Mental Health Center, Qingpu, Shanghai 201700, China; 3. Municipal Center for Disease Control and Prevention, Shanghai 200336, China
  • Received:2000-04-05 Revised:2000-05-24 Online:2001-01-30 Published:2001-01-30

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摘要： 目的与方法:以聚合酶链式反应(PCR) 技术对上海“本地人”正常人群GSTT1 和GSTM1 基因型多态性进行了研究。结果:上海“本地人”正常人群中GSTT1 纯合缺损基因型和GSTM1 纯合缺损基因型的比率分别为48153 %和54140 % ,与上海市区正常人群中两种基因型的分布比率(分别为49132 %和48186 %) 没有显著差别。GSTT1 - GSTM1 综合基因型4 种状态在两个人群中的分布频率也没有显著差别。结论: GSTT1 和GSTM1 基因型多态性在同为上海地区居民的上海“本地人”正常人群和上海市区正常人群中呈均一分布。

关键词: GSTT1 和M1 基因型, 多态性, 上海“本地人”正常人群

Abstract: Purpose and Methods : Population polymorphisms of the GSTT1 and M1 genes in the Shanghai“indigene”group were evaluated using the PCR procedure. Results : In this group , the f requencies of GSTT1 null and GSTM1 null genotype are 48. 53 % and 54. 40 % , respectively. No significant differences were detected between urban individuals (49. 32 % and 48. 86 % , respectively) and an“indigene”group in suburb of Shanghai for GSTT1 and GSTM1 genotypes alone , as well as for four combined genotypes of GSTT1 and GSTM1. Conclusion : Between the“indigene”population in remote suburb and the urban population in downtown of Shanghai the genetic polymorphism dist ribution of GSTT1 and GSTM1 genes is proved to be homogenous.

Key words: GSTT1 and GSTM1 genes, genotype polymorphism, “indigene”Shanghai population

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