癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (6): 347-348.doi: 10.3969/j.issn.1004-616x.2004.06.009

• 论著 • 上一篇    下一篇

姜黄水提液抗氧化与抑瘤作用的初步研究

陈 华,王志红,汪家梨,陈铁辉,薛常镐   

  1. 福建医科大学预防医学实验中心,福建 福州 350004
  • 收稿日期:2004-02-19 修回日期:2004-06-30 出版日期:2004-11-30 发布日期:2004-11-30
  • 通讯作者: 陈 华

Preliminary Study on Antioxidative and Antitumor Effect of Curcuma Longa L Fluid on H22 Tumorigenic Mouse

CHEN Hua, WANG Zhi-hong, WANG Jia-li, et al   

  1. Lab center for preventive medicine, Fujian medical University,Fuzhou 350004, China
  • Received:2004-02-19 Revised:2004-06-30 Online:2004-11-30 Published:2004-11-30
  • Contact: CHEN Hua

摘要: 背景与目的:观察姜黄水提液对荷H22肝癌小鼠实体瘤的抑制作用及其对荷瘤鼠体内抗氧化能力的影响。材料与方法: 建立移植性H22肝癌小鼠实体瘤的模型,灌胃给药,观察姜黄水提液及纯姜黄素给药后各处理组小鼠实体瘤重,肝重,脾重以及GSH、SOD的变化情况。结果: 纯姜黄素组抑瘤率为37.97 %,姜黄水提液各剂量组未见抑瘤作用。姜黄水提液与纯姜黄素均使荷瘤鼠体内GSH和SOD水平升高, 两者效果相似。结论: 中药姜黄水提液对H22肝癌小鼠实体瘤抑制作用不明显;但是姜黄水提液和纯姜黄素均能提高实验小鼠体内的GSH和SOD的水平,有良好的提高体内抗氧化能力作用。

关键词: 姜黄, H22, 抗肿瘤, 抗氧化

Abstract: BACKGROUND & AIM: To study the antioxidative and antitumor effcts of Curcuma longa L decoction on H22 tumorigenic mouse. MATERIAL AND METHODS: The H22 tumorigenic mice were oral administrated with the decoction with 24 g /kg, 12 g/kg and 6 g/kg curcuma longa L respectively for 8 days. Weight of tumor, both GSH and SOD activities of animal blood were determined. RESULTS: Inhibition of tumor growth was found for curcuma longa L decoction. But curcuma longa L decoction could significantly increase the levels of GSH and SOD on H22 tumorigenic mice blood. CONCLUTION: In this investigation, Curcuma longa L decoction has no obvious antitumor effect, but has antioxidative effect on H22 tumorigenic mice.

Key words: Curcuma longa L, H22, antitumor, antioxiditant