癌变·畸变·突变 ›› 2005, Vol. 17 ›› Issue (6): 386-388.doi: 10.3969/j.issn.1004-616x.2005.06.019

• 检测研究 • 上一篇    下一篇

一起放射性伤害事故受照者1.5年后染色体畸变随访观察

陈 英;孙偶君;骆亿生;刘秀林   

  1. 军事医学科学院放射医学研究所
  • 收稿日期:2004-11-29 修回日期:2005-03-15 出版日期:2005-11-30 发布日期:2005-11-30
  • 通讯作者: 陈 英

A Follow-up Study on Chromosomal Aberrations in the Victim of Radiation Injury Accident After 1.5 Years

CHEN Ying; SUN Ou-jun; LUO Yi-sheng; LIU Xiu-lin   

  1. Institute of Radiation Medicine, Academy of Military Medical Sciences
  • Received:2004-11-29 Revised:2005-03-15 Online:2005-11-30 Published:2005-11-30
  • Contact: CHEN Ying

摘要: 背景与目的:对广州放射性伤害事故受照者进行远后效应随访,观察迁延照射的细胞遗传学损伤特点。材料与方法:常规染色体畸变与G-显带核型分析。结果:双着丝点畸变下降缓慢;染色体总畸变率26 %,其中以易位等稳定性畸变为主,未发现克隆样核型改变。结论:迁延照射造成的细胞遗传学损伤较一次照射严重,且修复缓慢。

关键词: 迁延照射, 染色体畸变, 易位, 远后效应

Abstract: BACKGROUND & ATM: To follow late effects of a victim in a radiation injury accident and observe cytogenetic characteristics of a continual irradiation. MATERIAL AND METHODS: Conventional chromosomal aberrations and G-banded kayrotype analysis. RESULTS: There are little decline in dicentrics. Stable aberrations such as translocations play dominant role in total aberration frequency of 26 %. Clonal aberrations are not yet observed. CONCLUTION: There are more severe cytogenetic damage and slower repair in continual exposure to radiation than in single irradiation.

Key words: continual exposure, chromosomal aberrations, translocation, late radiation effect