关键词: Survivin, P53, 膀胱肿瘤, 移行细胞癌, 复发

Abstract: 【ABSTRACT】 BACKGROUND ＆ AIM： To explore the correlation between up-regulated expressions of Survivin and P53 proteins in the tumor tissues and relapse of transitional cell carcinoma (TCC) of the bladder. MATERIALS AND METHODS： Survivin and P53 proteins in the paraffin-embedded tumor tissues derived from 75 cases of TCC were examined by immunohistochemical staining. The expressions of the two proteins and the pathological grading were assessed, using Mantel-Haenszel analysis to calculate the odds ratios and significance level for difference of the indicators between the relapse and non-relapse groups of the TCC patients. RESULTS： The positive staining rates of Survivin in cytoplasm, Survivin in nuclei, P53, and cytoplasmic Survivin plus P53 were 76.0％, 30.67％, 53.33％ and 84.0％, respectively. The sensitivity for predicting the relapse were 87.50％, 37.50％, 71.88％ and 96.88％, respectively. The specificities were 32.56％, 74.42％, 61.90％ and 25.58％, respectively. The relative risks for the relapse were as following, Survivin (cytoplasm): OR=3.38, 95％CI (0.99－11.52), P=0.044; P53: OR=3.91, 95％CI (1.46－10.45), P=0.005; Survivin plus P53: OR=10.66, P=0.0087. The odds ratios by pathological grading classification were, P53: OR=3.41, P=0.016; P53 plus Survivin: OR=8.86, P=0.022. CONCLUSION： Over-expression of P53 protein in the tumor tissues might suggest a high risk for recurrence of bladder TCC, whereas the association between overexpression of Survivin and relapse of TCC was not demonstrated.

Key words: survivin, P53, bladder cancer, transitional cell carcinoma, relapse