肝细胞程序性坏死的研究进展

doi:10.3969/j.issn.1004-616x.2016.03.017

摘要/Abstract

摘要： 程序性坏死作为一种新发现的受信号分子调控的细胞死亡方式,参与多种疾病的发生和发展过程。与通常认为的坏死、凋亡和自噬不同,程序性坏死具有特异的分子机制,且其信号通路中的相关分子正成为人们研究的热点。近期有研究表明,程序性坏死均参与急性或慢性肝损伤、肝纤维化等过程,并与肝脏炎性疾病的发生发展有着密切的关系。因此,本文就程序性坏死的分子机制及其与肝细胞死亡的关系进行综述,为预防多种形式的肝损伤和治疗肝脏疾病提供新的思路。

关键词: 程序性坏死, 分子机制, 肝损伤, 炎症

中图分类号:

R994.6

杨舒筠, 张华俊, 白剑英. 肝细胞程序性坏死的研究进展[J]. 癌变·畸变·突变, 2016, 28(3): 239-242.

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