环状RNA在食管癌中的研究进展

doi:10.3969/j.issn.1004-616x.2021.03.015

摘要/Abstract

摘要： 环状RNA （circRNAs）是非编码RNA的一种，在真核细胞中广泛存在，其5'和3'末端连接在一起形成共价闭合环状RNA结构，因此不易被RNA酶降解，具有高度保守性和组织特异性。近年来研究发现，circRNAs并非错误的或无功能的转录片段，circRNAs能够和许多miRNA结合，发挥竞争性内源RNA作用；与RNA结合蛋白（RBP）结合，影响mRNA的表达等作用。circRNAs与恶性肿瘤、心血管疾病、神经系统疾病等发生发展密切相关，由于不同的circRNAs在特定肿瘤组织中呈现不同的表达特异性，因此有望成为新型肿瘤早期诊断的生物标志物和潜在的药物治疗靶点。

关键词: 食管癌, 环状RNA, 信号通路, 生物标志物

中图分类号:

R735.1

张玉领, 陈培. 环状RNA在食管癌中的研究进展[J]. 癌变·畸变·突变, 2021, 33(3): 241-245.

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