基于上转换纳米颗粒的肿瘤光动力治疗研究进展

doi:10.3969/j.issn.1004-616x.2024.01.012

摘要/Abstract

摘要： 肿瘤是目前威胁人类健康的主要疾病之一，传统的肿瘤治疗方法主要有手术、化学疗法和放射疗法等，但是上述手段存在局限性，如创伤性大、风险高、化疗药物的选择性差、产生耐药性和毒副作用大等。光动力疗法（PDT）是用特定波长照射肿瘤部位，活化选择性聚集在肿瘤部位的光敏剂，引发光化学反应破坏肿瘤细胞的过程。PDT因具有微创、靶向性强和不良反应少等优点，被广泛应用于抗肿瘤治疗。但是，传统的PDT治疗效果受到光敏剂的组织穿透能力弱、肿瘤微环境缺氧及免疫抑制等因素的限制。近几年来，上转换纳米颗粒（UCNPs）在生物医学领域的应用得到广泛关注。由于UCNPs具有毒性低、化学稳定性和光稳定性好等优点，具有将近红外光转换为紫外-可见光的特点，有望解决传统PDT存在的问题。本文主要概述了基于UCNPs的PDT在抗肿瘤领域的研究进展，并对其未来应用进行展望。

关键词: 光动力疗法, 上转换纳米颗粒, 肿瘤治疗, 光敏剂

中图分类号:

R730.51

王芳, 孙照刚, 褚洪迁. 基于上转换纳米颗粒的肿瘤光动力治疗研究进展[J]. 癌变·畸变·突变, 2024, 36(1): 70-76.

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