枸杞多糖对Nrf2信号通路调控作用的研究进展

doi:10.3969/j.issn.1004-616x.2024.01.013

摘要/Abstract

摘要： 枸杞多糖（LBP）是枸杞子的主要有效成分，已在基础研究中证实其具有抗氧化、抗肿瘤、增强免疫、降低血糖和血脂等作用，并在辅助治疗原发性肝癌、高脂血症中取得良好效果，因此在临床治疗上具有良好的应用前景。核因子E2相关因子2（Nrf2）是细胞内抗氧化和抗炎症损伤的关键调节因子。大量文献报道LBP可以通过激活Nrf2信号通路，预防或延缓多种疾病的进程。本文对枸杞多糖调控Nrf2信号通路发挥抗氧化、减轻炎症反应、调控细胞凋亡进程等作用进行综述，以期为后续的相关研究提供参考。

关键词: 枸杞多糖, Nrf2信号通路, 氧化应激, 细胞凋亡, 自噬

中图分类号:

Q291

林鹏, 张璨, 杨玉, 杨光远, 刘明远. 枸杞多糖对Nrf2信号通路调控作用的研究进展[J]. 癌变·畸变·突变, 2024, 36(1): 77-79.

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