miR-22、miR-34a与叶酸介导的一碳代谢在非小细胞肺癌和肝细胞癌中的调控作用

doi:10.3969/j.issn.1004-616x.2016.04.015

摘要/Abstract

摘要： 一碳代谢（OCM）是涉及DNA合成与基因表达的重要生物学代谢系统，该系统功能障碍可导致DNA结构变异和基因表达异常等遗传损伤，最终引起肿瘤和多类遗传-环境相关疾病。MicroRNA （miRNA）具有重要的转录后调控功能，对OCM关键基因功能的调控可间接影响基因组稳定性。miRNA的异常表达与各种OCM所介导的肿瘤、机体损伤效应均具有一定相关性。miRNA自身功能及其下游调控的机制已成为肿瘤研究的热点。miR-22和miR-34a是已报道的与OCM相关的miRNA，研究它们对OCM关键基因表达调控的分子机制对于探索新的肿瘤和遗传-环境相关疾病诊疗思路具有重要价值。本文就非小细胞肺癌和肝细胞癌中与OCM关键基因相关的miRNA异常表达的研究进展作一综述，以进一步阐释miRNA参与调控肿瘤发生的分子机制。

关键词: microRNA, 一碳代谢, 肿瘤, 非小细胞肺癌, 肝细胞癌

中图分类号:

R730.231

李超, 倪娟, 徐伟江, 汪旭. miR-22、miR-34a与叶酸介导的一碳代谢在非小细胞肺癌和肝细胞癌中的调控作用[J]. 癌变·畸变·突变, 2016, 28(4): 317-320.

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