细胞分裂周期相关因子2的研究进展

doi:10.3969/j.issn.1004-616x.2023.04.014

摘要/Abstract

摘要： 细胞染色体非整倍体的出现是导致肿瘤发生发展的重要原因之一，常由细胞周期检查点、DNA损伤修复、染色体分离、核膜重塑等异常调控导致。细胞分裂周期相关因子2(CDCA2)是细胞周期分裂相关基因家族的成员之一。越来越多的文献报道，CDCA2在多种肿瘤中异常表达，它对细胞基因组稳定性的维持具有重要作用。本文对CDCA2的结构与功能、CDCA2的作用机制及CDCA2与肿瘤的关系的研究进展等进行综述，期望为肿瘤的治疗提供新思路。

关键词: CDCA2, 基因组不稳定性, 有丝分裂, DNA损伤修复, 肿瘤

中图分类号:

Q291
R34

杜威, 李仁燕, 杨丹. 细胞分裂周期相关因子2的研究进展[J]. 癌变·畸变·突变, 2023, 35(4): 320-324.

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