癌变·畸变·突变 ›› 1998, Vol. 10 ›› Issue (2): 98-101.doi: 10.3969/j.issn.1004-616x.1998.02.009

• 论著 • 上一篇    下一篇

有机锗( Ge - 132) 对大鼠肝细胞色素P450 、EROD 活性抑制作用的研究

夏清林　莫白耀　杜琰琰　麦惠霞   

  1. 广州市卫生防疫站毒理科　广州　510080
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-03-30 发布日期:1998-03-30

STUDY ON THE INHIBITION OF CYT P450 CONTENT AND EROD ACTIVITY OF LIVER MICROSOMAL PREPARATION BY ORGANOAERMANIUM COMPOUNDS ( G- 132) IN RATS

Xia Qinglin , Mo ziyao , Du Yanyan , Mai Huixia   

  1. Antiepidemic station of GuangZhou , GuangZhou 　510080
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-03-30 Published:1998-03-30

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摘要： 利用雄性SD 大鼠每日经口给予有机锗( Ge - 132) 100 、250 、500mg/ kg 连续二十五d ,发现高剂量组的肝细胞色素P450受到明显抑制(P < 0. 05) 。对P448的标志酶乙氧基异吩口恶唑脱乙氧基酶( EROD) 的抑制也近50 %;动物以Ge - 132 500mg/ kg/ d 预先处理20d ,再分别给予苯巴比妥钠盐( PB) 、3 - 甲基胆蒽(3 - MC) ,发现Ge - 132 对PB 诱导P450的抑制不明显,而对3 - MC 诱导EROD 的抑制仍达33 %。

关键词: 有机锗( Ge - 132), P450, EROD 活性, 抑制作用

Abstract: Male SD rat s were fed orally with Ge - 132 100 , 250 and 500mg/ kg each day for 25days , Cyt P450 of liver cell of high dose group was inhibited significantly ( P < 0. 05) , EROD activity was also inhibited about 50 percent in the group compared with the cont rol. The animals were pret reated with Ge - 132 500mg/ kg/ d for 20 days , then give PB and 3 - MC , found that the inhibition of P450 induced by PB was not obvious , but there was 33 percent inhibition of EROD activity induced by 3 - MC.

Key words: Organogermaninm Compounds ( Ge - 132), P450, EROD activity, Inhibition

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