癌变·畸变·突变 ›› 2004, Vol. 16 ›› Issue (4): 237-238.doi: 10.3969/j.issn.1004-616x.2004.04.016

• 研究简报 • 上一篇    下一篇

胃癌患者的染色体畸变分析

陈兰英,赵 桢,侯玉杰,刘瑞芳,姬晓娜,朱 涛,方改霞   

  1. 平顶山工学院生物工程系,河南 平顶山 467001
  • 收稿日期:2004-01-14 修回日期:2004-02-19 出版日期:2004-07-30 发布日期:2004-07-30
  • 通讯作者: 陈兰英

An Analysis of Chromosome Aberrance of the Gastric Cancered

CHEN Lan-ying,ZHAO Zhen,HOU Yu-jie,et al   

  1. Biological Engineering Department,Pingdingshan Institute College,Henan,Pingdingshan 467001,China
  • Received:2004-01-14 Revised:2004-02-19 Online:2004-07-30 Published:2004-07-30
  • Contact: CHEN Lan-ying

摘要: 背景与目的:研究胃癌患者的染色体畸变情况。材料与方法:以临床已确定的未经放疗和化疗的26例胃癌患者作为研究组,以健康、无不良嗜好、无有害物接触史的志愿者26人作为对照组。采取研究组和对照组中每一例的外周血样本,各培养3个培养物,分别用于进行微核率、姐妹染色单体交换率、染色体结构和数目畸变率等指标的研究。结果:研究组均高于对照组,显示出研究组和对照组的微核率、染色单体交换率、染色体畸变率均存在着差异性。结论:染色体畸变可能是胃癌发生的细胞学基础。

关键词: 胃癌患者, 染色体, 畸变, 淋巴细胞

Abstract: ABACKGROOND ALM:Research on the chromosome aberrance of the gastric cancer. MATERIAL AND MOTHDS: Regard 26 gastric cancered patients as a research group,diagnosed with no radioactive and chemical theatments.Regard 26 volanteers as contrast group.Use 3 culture medium which cultivate through each of circumjacent hema-sampling from both group for the research on microkernel rate,sibling chromatid exchanged rate and chromosome aberrance rate of the configuration and number.RESULT: The rates on the research group significantly higher than that on the contrast group.Via statistical analysis and process, χ2 test P<0.01 which suggest that there are notable discrepancy on both groups. CONCLUSION: Chromosome aberrance probably are the cytological elements causing gastric cancer.

Key words: Gastric cancer, Chromosome, Aberrance, Lymphocyte