关键词: 硝酸羟胺, 急性毒性, LD50, 骨髓细胞微核, 染色体畸变

Abstract: BACKGROUND ＆ AIM: To explore the acute toxicity and LD50,and study the genetic damage of bone marrow cells induced by Hydroxylammonium Nitrate. MATERIAL AND METHODS: After celiac administration of HAN in mice,the mortality and the physiological changes were observed; Chromosome aberration test,micronucleus test in mouse were used. RESULTS: The LD50 of HAN in male on 24 hour and 14 day was 186 mg/kg(185～187 mg/kg) and 183 mg/kg (182～184 mg/kg),respectively. No pathological change of the organs was found. There were significant findings in chromosome aberration and micronucleis rates in experimental groups compared with those of the negative control group(P<0.05). CONCLUSION: According to the standard of grading of acute toxicity,HAN belongs to the moderate class. The genetic damage of bone marrow cells can be induced by Hydroxylammonium Nitrate.

Key words: hydroxylammonium nitrate(HAN), acute toxicity, LD50, bone marrow cells, chromosomes, micronuclei