丹参对丝裂霉素C 诱发小鼠生殖细胞遗传损伤的防护作用研究

doi:10.3969/j.issn.1004-616x.1998.01.012

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (1): 39-041.doi: 10.3969/j.issn.1004-616x.1998.01.012

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A PROTECTIVE EFFECT OF SALVIA MILTIORRHIZA ON GENETIC DAMAGE OF GERM —CELL INDUCED BY MITOMYCINC (MMC)

Zhao J ingchun ,Yang J iena ,Sun Yimei

Normal College of V ocational A nd technical Training Of BUU , Beijing 100011

Received:1900-01-01 Revised:1900-01-01 Online:1998-01-30 Published:1998-01-30

Abstract

Abstract: In this paper ,the relationship between the MMC inducing effect and protecting effect of Salvia mitiorrhiza ,was studied in germ - cell of Kunming mice 。Male mice divided randomly into eight groups with 15 mice each group 。In experimental groups different dose of Salvia mitiorrhiza and same dose of MMC were administ rated。The chromosome aberration (CA) of spermatogonia ,sperm aberration and micronucleus(MN) of early spermatids were observed。The results showed that chinese medicine it self has no genetoxic effect , bus can significantly decrease CA ,MN and sperm aberration frequencies induced by MMC ( P < 0. 01) . The result s indicated that the chinese medicine Salvia mitiorrhiza may be an antimutagen。

Key words: Salvia miltiorrhiza, Germ - cell, Sperm aberration, Chromosome aberration, Micronucleus

Zhao J ingchun , Yang J iena , Sun Yimei. A PROTECTIVE EFFECT OF SALVIA MILTIORRHIZA ON GENETIC DAMAGE OF GERM —CELL INDUCED BY MITOMYCINC (MMC)[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(1): 39-041.

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A PROTECTIVE EFFECT OF SALVIA MILTIORRHIZA ON GENETIC DAMAGE OF GERM —CELL INDUCED BY MITOMYCINC (MMC)

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