Abstract: The Mutageicity of Graniset ron was studied by Ames test , chromosome aberration assay of mammlian cell (CHL) in vit ro and mouse marrow micronucleus assay. The results showed that Graniset ron had no mutagenicity on salmonella typhimurium st rain TA97 , TA98 , TA100 and TA102 with or mithout S9 mix. Chromosome aberration rates induced by 15μg/ ml and 30μg/ ml doses with S9 mix were 6 % and 7 % respectively , Possible postive. The freqaency of male mice micronuleus rate induced by 4. 8mg/ kg dose were signifioant disfereonces as Compared with negative cont rocl ( P < 0. 01) , The result s showed that Graniset ron more than 4. 8mg/ kg Graniset ron Could also induce mouse marrow micronucleus rates increase , So. Graniset ron is mutagenic.

Key words: Graniset ron, Ames test, Chromosome aberration test, Micronucleus test, mutagenicity