OF-3 的致突变、致畸的研究

doi:10.3969/j.issn.1004-616x.1998.02.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1998, Vol. 10 ›› Issue (2): 101-103.doi: 10.3969/j.issn.1004-616x.1998.02.010

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STUDIES ON THE MUTATION AND TERATOGENICITY OF OF-3

Zhou Liguo 　Zhou Mojiong 　Shao Xuexiwi 　Cheng Ling

School of Pharmacy , Tongji Medical University , Wuhan 430030

Received:1900-01-01 Revised:1900-01-01 Online:1998-03-30 Published:1998-03-30

Abstract

Abstract: In this paper , the mutation and teratogenic effect of the OF23 were investigated. The LD50 was determined as 3. 3g/ kg in mice by oral. The result s indicated that the micronucleus rate was not significant difference ( P > 0. 05) in dosage of 0. 17 - 1. 65/ kg/ day and the marrow chromosome aberration was negative in dosage of 0. 03 - 0. 17g/ kg ,but in teratogenic test , the weight of the female rat s and its fetus were lighten with the dosage increasing , this result shows the OF23 have toxic effect on fetus in long2term administ ration.

Key words: OF-3, animal experiment, micronucleus, marrow chromosome aberration, teratogenic effect

Zhou Liguo 　Zhou Mojiong 　Shao Xuexiwi 　Cheng Ling. STUDIES ON THE MUTATION AND TERATOGENICITY OF OF-3[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(2): 101-103.

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STUDIES ON THE MUTATION AND TERATOGENICITY OF OF-3

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