经络调理胶囊抗突变作用的研究

doi:10.3969/j.issn.1004-616x.1998.04.010

Abstract

Abstract: The mutagenic and antimutagenic effect s of channel modulating capsule (CMCA) were studied with micromucleus test in bone marrow cells of mice (in vivo) and in the lymphocytes of human blood(in vit ro) . The main result s are as follows ①10 - 50μg/ ml CMCA did not induce micronucleus formation in lymphocytes in vit ro. 10 - 50μg/ ml CMCA inhibited induced micronucleus formation byγ2rays significantly. ②No significant effect of 10 - 50mg/ kg body weight (B.W. ) on MNF in polychromatic erythrocytes (PCE) of mice was found. 10 - 50mg/ kg B. W. CMCA supressed significantly cyclophosophamide (CP)2induce micronucleus formation in PCEs of mice. These result s suggested that CMCA could be used in tumor clinic to reduce side effect s of radio - and chemotherapy.

Key words: Channel modulating capaule (CMCA), Micronucleus, γ2ray, Cyclophosophamide (CP), Bone marrow cells of mice

Wu J ianzhong Xue Kaixian Ma Guojian Sheng Zongli Chen Sengqing. STUDY ON ANTIMUTAGENIC OF CHANNEL MODULATING CAPSULE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1998, 10(4): 233-235.

[1]	SHI Wenjing, ZHANG Jiqianzhu, ZHU Jiangbo, ZHANG Xiaofang, WANG Ruina, DAI Xiaoyu, REN Lijun, TIAN Yijun. Evaluation of genotoxicity of diphenhydramine hydrochloride and caffeine compound [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 149-153,157.
[2]	CAI Qi, GAO Deyu, SHI Jianfeng, YU Hao, HAN Yan, YANG Liu, ZHAO Lei, WANG Zhaoxu. Potential use of tree shrew as an animal model for the micronucleus test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 370-374,382.
[3]	LU Xue, TIAN Xuelei, ZHAO Hua, CAI Tianjing, TIAN Mei, LIU Qingjie. Use of the micronucleus assay to estimate partial radiation exposure dose in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 193-196.
[4]	ZHAO Hua, LU Xue, CAI Tianjing, TIAN Mei, LIU Qingjie. Effects of age and gender on formation of nucleoplasmic bridges in peripheral blood lymphocytes [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 48-52.
[5]	CAO Yiyi, LIU Weiying, YOU Xinyue, XI Jing, Chen Ruixue, ZHANG Xinyu, LUAN Yang. In vitro genotoxicity evaluation of BDE-3, BDE-47 and BDE-209 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 15-20,28.
[6]	WANG Quankai, XIE Guangyun, MA Shunpeng, GUO Haoran, WUHAN Baolier, SONG Jiayang, XU Jianning. Genotoxicity evaluation of glycidyl methacrylate [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 479-482.
[7]	LI Ying, CHEN Xiaming, LI Hanrong, LUO Te. Genotoxicity of three kinds of electric mosquito repellents on plant root tip cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(5): 401-405,411.
[8]	WEN Hairuo, GUO Yajuan, HUANG Zhiying, WANG Xue, DAN Mo. Induction of cytotoxicity and DNA damage by iron oxide nanoparticles with different surface modifications in A549 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(6): 413-421.
[9]	XIA Ying, FU Shaohua, ZHANG Yinjing, WANG Wei. Genetic toxicity test of a pesticide, Paichongding [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 136-139.
[10]	CAO Yiyi, XI Jing, TANG Weifeng, YOU Xinyue, LIU Weiying, LUAN Yang. Genotoxicity evaluation of triclosan in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(1): 71-75.
[11]	WANG Zhi, LING Xi, ZHANG Guowei, GAO Jianfang, ZOU Peng, JING Che, LIN Zhetao, LIU Jinyi, CAO Jia, AO Lin. Effect of folic acid on DNA demethylation and chromosomal damage in mice after their inhalation exposure to 1, 3-butadiene [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(3): 189-193.
[12]	WANG Chao, RUAN Hongjie, DOU Jiexiong, DUAN Lian, ZHANG Hongwei. Use of the Vicia faba root tip micronucleus test to monitor the genotoxicity of tap water [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(6): 481-483,490.
[13]	WANG Chao, DUAN Lian, ZHANG Hongwei. Genetic toxicity of mercury,arsenic, formaldehyde and their combinations in Vicia faba root tip cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 383-387.
[14]	HAN Tianjiao, ZHOU Changhui, CHANG Yan. Establishment a method for genotoxicity evaluation of ethyl methanesulfonate in rats using Comet and flow micronucleus assays [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 277-280.
[15]	YING Jian, HAO Binxiu, MENG Qingjia, CHEN Ran, WANG Liming, WANG Chunling. Acute toxicity and genotoxicity of crude water extracts from tea mistletoe Viscum Liquidambaricolum Hayata [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 306-309,324.

STUDY ON ANTIMUTAGENIC OF CHANNEL MODULATING CAPSULE

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments