亚硝酸钠和N- 甲基苄胺的遗传毒性研究

doi:10.3969/j.issn.1004-616x.1999.05.006

Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (5): 227-229.doi: 10.3969/j.issn.1004-616x.1999.05.006

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THE STUDY ON GENOTOXICITY OF SODIUM NITRITE AND N2METHYLBENZYLAMINE

Hong Zhenfeng , Wang Zhenxian , Gao Bizhen , Xi Biyi , Chen Ling

Fujian College of Traditional Chinese Medicine , Fuz hou

Received:1999-03-29 Revised:1999-06-14 Online:1999-09-30 Published:1999-09-30

Abstract

Abstract: The genotoxicity of sodium nit rite and N-methylbenzylamine were detected. The result s showed that sodium nit rite and N2methybenzylamine did not induce acute genotoxicity ( P > 0. 5) ,but had a middle and long term genotoxicity. Exposed for long term , the gast ric ant rum and exophagus in the rat s showed different levels hyperplastic change ; and the per mil rate of micronuclei of marrow cells increased ; the thymus gland indexes lowered.

Key words: Sodium nit rite, N-methylbenzylamine, genotoxicity

Hong Zhenfeng , Wang Zhenxian , Gao Bizhen , Xi Biyi , Chen Ling. THE STUDY ON GENOTOXICITY OF SODIUM NITRITE AND N2METHYLBENZYLAMINE[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 1999, 11(5): 227-229.

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THE STUDY ON GENOTOXICITY OF SODIUM NITRITE AND N2METHYLBENZYLAMINE

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