肝细胞癌P53 蛋白的表达及临床意义的研究

doi:10.3969/j.issn.1004-616x.2000.02.010

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (2): 93-094.doi: 10.3969/j.issn.1004-616x.2000.02.010

Previous Articles Next Articles

EXPRESSION OF P53 PROTEIN AND CLINICAL SIGNIFICANCE IN HUMAN HEPATOCELLULAR CARCINOMA

GAI Xiao - dong , LI Guo - li , Wang Yian , Dong Zhi - heng

Department of Pathology , Jilin Medical College , Jilin 132001 , China

Received:1999-08-03 Revised:1999-11-25 Online:2000-04-30 Published:2000-04-30

Abstract

Abstract: Purpose and Methods : To evaluate the P53 protein expression and clinical significance in human hepatocellular carcinoma ( HCC) , the expression of P53 protein was detected in HCC by immunohistochemical method. Results : The result s showed that P53 protein was positive in 49 % (36/ 74) of HCC , and there was significant correlation between P53 protein expression and HCC histologic grade. Conclusion : The results suggested that the over2expression of P53 caused by P53 gene mutation is a common kind of molecular st ructure changes in HCC. In addition , P53 protein may be used as a valuable biomaker of HCC.

Key words: P53 gene, mutation, immunohistochemist ry, hepatocellular carcinoma.

CLC Number:

R73517

GAI Xiao - dong , LI Guo - li , Wang Yian , Dong Zhi - heng. EXPRESSION OF P53 PROTEIN AND CLINICAL SIGNIFICANCE IN HUMAN HEPATOCELLULAR CARCINOMA[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(2): 93-094.

[1]	XU Qilu, GAO Hui, RAN Xuehong, WANG Junjun, ZHANG Junying, LIU Liping. Gene mutation and clinical correlation analyses of myeloid leukemia with abnormal karyotypes [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 296-301,306.
[2]	SHI Hailin, HE Tianji, LIU Feng, CAI Menghui, GE Bo. Prognostic value of TCGA-database mutation burden in muscle-invasive bladder cancers [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 430-437,443.
[3]	ZHANG Jiahong, ZHANG Qingying, ZHANG Yanhong, CHEN Jialian, XIE Fang, LIU Ruiguo, WU Rong, WU Longfei. Screening and evaluation of gene mutations in a familial hypercholesterolemia family [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(3): 229-232,245.
[4]	CAO Yiyi, LIU Weiying, YOU Xinyue, XI Jing, Chen Ruixue, ZHANG Xinyu, LUAN Yang. In vitro genotoxicity evaluation of BDE-3, BDE-47 and BDE-209 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 15-20,28.
[5]	ZHENG Kai, WANG Bingyu, XU Xinyun, GENG Hong, HUANG Haiyan, LIU Wei, LONG Dingxin. Mutagenicity of PM_2.5 samples from Shenzhen and Taiyuan [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 483-487.
[6]	YANG Jinru, QIN Lulu, ZHU Yongfei. Meta analysis on association between JAK2 gene mutation and susceptibility to chronic myeloid leukemia [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 231-237.
[7]	LI Ruowan, ZHOU Changhui, HUANG Pengcheng, CHANG Yan. Establishment of an in vitro PIG-A gene mutation assay based on TK6 cells for genotoxicity tests [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 242-248.
[8]	ZHANG Feng, ZHAO Long, FAN Jinping, WU Xueling, MENG Shufang. Induction of tumor in NIH mice by the plasmid containing the V112A and Q61R mutated HRAS [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(1): 1-8.
[9]	SHANG Pingping, HUA Chenfeng, XIE Fuwei, LI Xiang. Mutagenicity of cigarette samples with different tar releases in the TK gene mutation assay [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(1): 49-52.
[10]	WANG Ping, LIU Bingfeng, YANG Yunfeng, CAI Yuwei, TAN Na, YAO Lijuan, LUO Ranran, ZHANG Guo. Mutation frequencies of tumor-related genes in the pancreatic tissues of diet-induced obese mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(3): 182-187.
[11]	XIA Ying, FU Shaohua, ZHANG Yinjing, WANG Wei. Genetic toxicity test of a pesticide, Paichongding [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 136-139.
[12]	GUO Xiao, WANG Rui, WU Juan, JI Xiaokun, WANG Heng, ZHANG Yan, MA Yang, DU Yun. Significance of EGFR gene mutation in fresh cytological specimens of lung adenocarcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(1): 67-70.
[13]	CHANG Chen, ZHAO Xiaohan, JIANG Ye, XU Xin, CAI Yan, PEI Yuhui, ZHANG Yu, HAO Jiajie, WANG Mingrong. Identification of predominant genome DNA alterations and their clinical implication in esophageal squamous cell carcinoma [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(1): 1-6.
[14]	MENG Xiaoqing, FANG Zhijia, WEI Hongyan, YANG Zhanju, HUANG Zhiwei. Genotoxicity investigation of tri- and hexavalent chromium using a yeast SUP4-o mutation assay [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2017, 29(1): 65-69.
[15]	YUAN Ye, CHEN Dandan, JING Shufang, YU Yongsheng, CHEN Jianheng, WU Chunqi, SHI Chang. Mutagenic effects of N-(n-butyl)-thiophosphorictriamide in somatic and germ cells of mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(6): 432-437.

EXPRESSION OF P53 PROTEIN AND CLINICAL SIGNIFICANCE IN HUMAN HEPATOCELLULAR CARCINOMA

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments