重质芳烃的致突变性研究

doi:10.3969/j.issn.1004-616x.2001.02.017

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2001, Vol. 13 ›› Issue (2): 89-091.doi: 10.3969/j.issn.1004-616x.2001.02.017

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STUDY ON THE MUTAGENICITY OF HEAVYWEIGHT AROMATIC HYDROCARBON

WANG Wei1, YE Lin1, ZHU Jian-hua1, WU Liu-song2, HU Dao-hua2, WANG An-lian1, FENG Xue-qing1, WANG Qiu-ping1, BAO Jun-hui1

1. Anhui Institute of Occupational Health, Hefei 230022, China, 2. Anqing Pet rochemical works, Anqing 246001, China

Received:2000-06-15 Revised:2000-08-17 Online:2001-04-30 Published:2001-04-30

Abstract

Abstract: Purpose and Methods : The mutagenicity of heavyweight aromatic hydrocarbon (HAH) was studied by Ames test , micronucleus test and sperm deformity test in mice , sister chromatid exchange test in human beings. Results : Ames test was negative in all dosage groups. The f requencies of bone marrow micronucleus were increased significantly at the dose of 316～1 580 mg/ kg·bw. The result of SCE showed that the f requencies of SCE in two groups (0. 5 mg/ ml and 5. 0 mg/ ml) were significantly increased. In mouse spermatic deformity test , the rate of spermatic deformity was statistically higher at 1 580 mg/ kg·bw than that of negative group.Conclusion : HAH has potential mutagenicity for somatic cells in mice and human being , and for sperm in mice.We should pay attention to it s occupational exposure and it s application.

Key words: heavyweight aromatic hydrocarbon, Ames test, micronucleus, Sister chromatid exchange, spermdeformity

CLC Number:

R994. 3

WANG Wei, YE Lin, ZHU Jian-hua, WU Liu-song, HU Dao-hua, WANG An-lian, FENG Xue-qing, WANG Qiu-ping, BAO Jun-hui. STUDY ON THE MUTAGENICITY OF HEAVYWEIGHT AROMATIC HYDROCARBON[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(2): 89-091.

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STUDY ON THE MUTAGENICITY OF HEAVYWEIGHT AROMATIC HYDROCARBON

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