Abstract: BACKGROUND ＆ AIM： To study the effect of anti-mutation by testing bone marrow cells micronucleus and chromosome aberration with Acupunctur and Moxibustion. MATERIAL AND METHODS: 96 mice were divided 6 groups:1,normal control group;2,positive control group;3,prevention groupⅠ;4, prevention groupⅡ;5,treatment groupⅠ;6,treatment groupⅡ.In the 2～6 groups,all the mice were treated with ip. CP.50 mg/kg body weight,and in the 3～6 groups,the mice were acupuncted the acupuncture points of Zusanli,moxaed the acupuncture points of Guanyuan.At the end of experiment,all the mice were decapitated,tested bone marrow cells micronucleus and chromosome aberration. RESULTS: Compared with 1group,in 2 group,the bone marrow cells micronucleus and chromosome aberration were significantly highter. Compared with 2 group,in 3～6 groups,these indexes were significantly lower(P<0.01). Conclusion:Acupuncting the acupuncture points of Zusanli and moxaing the acupuncture points of Guanyuan can prevent or treat the bone marrow cells micronucleus and chromosome aberration of mouse,which increased by CP.

Key words: acupunctur and moxibustion, anti-mutation, mice, micronucleus, chromosome aberration