Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (4): 242-243.doi: 10.3969/j.issn.1004-616x.2004.04.018

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Study of Haizhenyuye(HY) Antatgonise Against the Mutation Effect Caused by Cyclophosphamida

SHANG Xi-Mei，QIAO Jian-wei，HOU Dian-jun，et al   

  1. Institute of Radiation Medicine of Shandong Academy of Medical Sciences,Jinan 250062, China
  • Received:2003-05-07 Revised:2003-12-25 Online:2004-07-30 Published:2004-07-30
  • Contact: SHANG Xi-Mei

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Abstract: BACKGROUND ＆ AIM: To study the anti-mutation effect of Haizhenyuye (HY) in order to provide some helpful informations to clinic. MATERIAL AND METHODS: The micronucleus test of mouse bone marrow cell and the sperm abnormality test in rats were used in this study.RESULTS: The frequencies of micronucleus and abnormal sperms caused by cyclophosphamide(CP)were reduced significantly by HY,and the more HY dose the more reduction of the frequencies(P<0.01). CONCLUSION: The results indicated that HY can significantly decrease the mutation of somatic and germ cells caused by CP.

Key words: Haizhenyuye, cycophosphamide, micronucleus test, sperm abnormality