Abstract: BACKGROUND ＆ AIM： To explore the predictive values of MMP-7 and MMP-9 in malignant transformation of hydatidiform mole. MATERIALS AND METHODS： The protein expressions of MMP-7 and MMP-9 were evaluated by immunohistochemistry in 18 normal villi,49 hydatidiform moles,in which 8 were malignantly transformed moles. The chemiluminescent immunoass was used to measure the level of HCG in 49 hydatidiform moles. RESULTS： The protein expressions of MMP-7 and MMP-9 were significantly higher in malignantly transformed moles than that in normal villi and nonmalignantly transformed moles(P<0.05). There was no statistical difference between normal villi and nonmalignant transformed mole(P>0.05). 8 hydatidiform mole cases which 3 cases persist positive and 5 cases up and down malignant into invasive mole. CONCLUSION： MMP-7 and MMP-9 may be involed in the invasion of the cytotrophoblast cells.Examining the expressions of MMP-7 and MMP-9 could be useful indexes for prediction of gestational trophoblastic disease and offer basis for clinical therapy.

Key words: matrix metalloproteinase-7, matrix metalloproteinase-9, hydatidiform mole