葡多酚对乳腺癌细胞雌激素受体表达的影响

doi:10.3969/j.issn.1004-616x.2008.01.005

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2008, Vol. 20 ›› Issue (1): 19-021.doi: 10.3969/j.issn.1004-616x.2008.01.005

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The Effect of Grape Procyanidins on the Expression of Estrogen Receptor in Breast Cancer Cells

LI Cong_cong, ZHONG Jin_yi

Medical College of Qingdao University,Qingdao 266021,Shandong, China

Received:2007-09-18 Revised:2007-10-28 Online:2008-01-30 Published:2008-01-30
Contact: ZHONG Jin_yi

Abstract

Abstract: BACKGROUND AND AIM: To study the effect of grape procyanidins(GPC) on the expression of estrogen receptor in breast cancer cells. MATERIALS AND METHODS: The MCF_7 cells were cultured with different concentrations of GPC. The MCF_7 cells were divided into four groups: 200,100,10 μg/ml GPC groups and control group. The expressions of ER and Bcl_2 protein were assessed by immunohistochemistry. The proliferation activity of breast cancer cells was evaluated by MTT assay. RESULTS: The expression of ER protein in 100 and 200 μg/ml GPC groups were(85.02±1.53)％ and(73.14±1.05)％, respectively. The proliferative activity of the cells were 0.365±0.009 and 0.283±0.008, respectively. Compared with control group, all the results mentioned were significantly decreased (P<0.05). CONCLUSION: GPC could inhibit the expression of ER protein and proliferative activity of breast cancer cells.

Key words: grape procyanidins, breast cancer, estrogen receptor, proliferative activity

LI Cong_cong, ZHONG Jin_yi. The Effect of Grape Procyanidins on the Expression of Estrogen Receptor in Breast Cancer Cells[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(1): 19-021.

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The Effect of Grape Procyanidins on the Expression of Estrogen Receptor in Breast Cancer Cells

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