人体痛风石中微塑料的定性与定量分析

doi:10.3969/j.issn.1004-616x.2023.05.006

Abstract

Abstract: OBJECTIVE:This study aimed at detecting whether microplastics existed in human tophi; and then qualitatively and quantitatively analyzing the detected microplastics; identifying compositions of tophi,exploring possible roles of microplastic accumulation in tophi formation in the joints,and then providing new ideas for the treatment of gout. METHODS: Samples of gouty tophus from 5 male patients (serum uric acid>500 μmol/L) were included for analysis,and pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) was used to detect 10 types of microplastics that might exist in tophi. RESULTS: More than or equal to 1 type of microplastic was detected in the tophi of 4 patients,and a total of 4 different types of microplastics (polystyrene,polyethylene,polyvinyl chloride,polyadiohexylenediamine) were identified. The results demonstrate that polystyrene (PS) and polyethylene (PE) had the highest detection rate,with average contents of 20.300 and 115.157 mg/kg,respectively. CONCLUSION: Microplastics can be detected in human tophi,which may be involved in and may play a certain role in the formation of human tophi.

Key words: microplastic, tophus, gout, health risks

CLC Number:

R994.6

HUANG Yubin, Lü Quanwei. Qualitative and quantitative analysis of microplastics in human tophi[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2023, 35(5): 360-365,373.

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Qualitative and quantitative analysis of microplastics in human tophi

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