Carcinogenesis, Teratogenesis & Mutagenesis ›› 1999, Vol. 11 ›› Issue (1): 11-013.doi: 10.3969/j.issn.1004-616x.1999.01.004

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STUDY ON THE ANTIMUTAGENIC EFFECT IN VIVO OF CORTEX ACANTHOPANASIA RADICIS

Liu Bing1, Pang Huimin1, Chen Minyi2   

  1. 1 Department of Medical Genetics, Norman Bathune University of Medical Sciences, ChangChun 　130021 　2 Shanghai Second Medical University, A ttached XinHua Hospital
  • Received:1998-04-06 Revised:1998-08-04 Online:1999-01-30 Published:1999-01-30

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Abstract: The antimutagenic effect of Cortex acanthopanasia Radicis (CAR) has been studied by mean of micronucleus test of mouse bone marrow polychromatic erythrocyte ( PCE) and mouse spermatid malformation test . The result s indicated that chinese medicine CAR it self has no genotoxic effect . The inhibition rates of CAR (1g/ kg ,2g/ kg ,4g/ kg) to micronuclei was respectively 73. 27 % ,50. 5 % and 63. 37 % ( P < 0. 01) ,and inhibition rates of CAR to spermatid malformation was 84 % (1g/ kg) , 81. 45 %(2g/ kg) and 73. 45 % (4g/ kg) ( P <0. 01) . It is suggested that CAR can significantly inhibit the genetic damage of germ cells and stomatic cells induced by MMC.

Key words: Cortex acanthopanasia radicis, mitomycin C(MMC), micronucleus test, sperm aberration