上海“本地人”正常人群hGSTP1 基因A1578G多态性研究

doi:10.3969/j.issn.1004-616x.2000.01.002

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (1): 6-007.doi: 10.3969/j.issn.1004-616x.2000.01.002

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POLYMORPHISM AT LOCUS A1578G OF HUMAN GLUTATHIONE S -TRANSFERASE P1 GENE IN SHANGHAI“INDIGES”POPULATION

MA Qing-wen1 , L IN Guo-fang1 , CHEN J i-gang2 , XIAN G Cui-qin2 , ZHA Yong-lin3 , LOU Ke-jian3 , SHEN Jian-hua1

1. Sino - German laboratory of Toxicology ( DCLT), Shanghai Institute of Entomology, Chinese Academy of Sciences, Shanghai 200025, China; 2. Municipal Center for Disease Control and Prevention, Shanghai 200336, China; 3. County Mental Health Center, Qingpu, Shanghai 201700, China

Received:1998-08-02 Revised:1999-11-19 Online:2000-01-30 Published:2000-01-30

Abstract

Abstract: Purpose and Methods : Population polymorphism at the locus of A1578G of human glutathione S -t ransferase P1 gene in an“Indigenous”Shanghainese group were investigated by PCR - RFL P approach. Results : The data showed that the population f requencies of genotypes Ile105/ Ile105 (AA) , Val105/ Val105 ( GG) and Ile105/ Val105 (AG) were 63. 9 % ,1. 2 % , 34. 9 % , respectively. Allele f requencies of Ile105 and Val105 were detected as 0. 813 and 0. 187 , respectively. The situation differs significantly f rom that of several Caucasian populations and Af rican Americans reported. Conclusion : Among different sub - population ( resident groups dist ributing in different areas) of Chinese population , GSTP1 A1578G locus proved to be of highly homogenous on the aspect s of allele f requency.

Key words: GSTP1 gene, population, polymorphism

CLC Number:

Q346. 5

MA Qing-wen , L IN Guo-fang , CHEN J i-gang , XIAN G Cui-qin , ZHA Yong-lin , LOU Ke-jian , SHEN Jian-hua. POLYMORPHISM AT LOCUS A1578G OF HUMAN GLUTATHIONE S -TRANSFERASE P1 GENE IN SHANGHAI“INDIGES”POPULATION[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(1): 6-007.

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POLYMORPHISM AT LOCUS A1578G OF HUMAN GLUTATHIONE S -TRANSFERASE P1 GENE IN SHANGHAI“INDIGES”POPULATION

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