癌变·畸变·突变 ›› 2005, Vol. 17 ›› Issue (1): 56-58.doi: 10.3969/j.issn.1004-616x.2005.01.019

• 检测研究 • 上一篇    下一篇

仙人掌原液毒性的初步研究

程　东;韩晓英;冯　宁;张天亮;李　慧   

  1. 山东省疾病预防控制中心， 山东　济南　250014
  • 收稿日期:2004-04-14 修回日期:2004-06-20 出版日期:2005-01-30 发布日期:2005-01-30
  • 通讯作者: 程　东

Study of Toxicity of Juice of Cactus

CHENG Dong;HAN Xiao-ying;FENG Ning;et al   

  1. Department of Toxicology, Shandong Center for Disease Prevention and Control，Jinan 250014, China
  • Received:2004-04-14 Revised:2004-06-20 Online:2005-01-30 Published:2005-01-30
  • Contact: CHENG Dong

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摘要： 背景与目的： 研究仙人掌原液的毒性。 材料与方法： 小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、大鼠30 d喂养试验。 结果： 仙人掌原液雌、雄小鼠LD50均大于20.0 g/kg，属无毒物质；Ames试验、微核试验和精子畸形试验结果均为阴性；大鼠30 d喂养试验结果显示该样品30 d喂养对大鼠各项观察指标未见毒性作用。结论： 在本次实验条件下，仙人掌原液为无毒物质，未显示有遗传毒性和亚急性毒性作用。

关键词: 仙人掌原液, 急性毒性试验, 遗传毒性试验, 30 d喂养试验

Abstract: BACKGROUND ＆ AIM: To study the toxicity of juice of cactus. MATERIAL AND METHODS: Acute toxicity test of mice,Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice,thirty days feeding study. RESULTS: Juice of cactus had no toxicity according to the acute toxicity (LD50>20.0 g/kg).The results of genetic toxicity test were all negative,including Ames test,micronucleus test and sperm shape abnormality test.The results of thirty days feeding study was also negative. CONCLUSION: Juice of cactus had no toxicity and had no genetic toxicity and subacute toxicity in this test. 　　

Key words: juice of cactus, acute toxicity test, genetic toxicity test, thirty days feeding study

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