高氡暴露地区人群中代谢酶CYP1A1基因多态性与肺癌易感性的关系

doi:10.3969/j.issn.1004-616x.2008.01.003

癌变·畸变·突变 ›› 2008, Vol. 20 ›› Issue (1): 11-014.doi: 10.3969/j.issn.1004-616x.2008.01.003

高氡暴露地区人群中代谢酶CYP1A1基因多态性与肺癌易感性的关系

齐雪松1，夏　英1，孙全富1，尚　兵1，吕慧敏3，程同心2，崔宏星1，冯顺治3，王利平1，王　浩3，孙粉珍3

1.中国疾病预防控制中心辐射防护与核安全医学所，北京　100088； 2.甘肃庆阳市地方病防治协调领导小组；3.庆阳市人民医院，甘肃　庆阳市　745100

收稿日期:2007-11-13 修回日期:2007-11-20 出版日期:2008-01-30 发布日期:2008-01-30

Association between Genetic Polymorphisms of CYP1A1 and Lung Cancer Susceptibility for People Living in High Radon-exposed Area

QI Xue-song1, XIA Ying1, SUN Quan-fu1, SHANG Bing1,LU Hui-ming1, CHENG Tong-xin2, CUI Hong-xing1, FENG Shun-zhi2,WANG Li-ping1, WANG Hao3, SUN Fen-zhen3

National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing

Received:2007-11-13 Revised:2007-11-20 Online:2008-01-30 Published:2008-01-30

摘要/Abstract

摘要： 背景与目的：研究高氡暴露地区人群中CYP1A1基因多态性与肺癌易感性的关系。材料与方法：采用病例-对照研究方法，以基因体外扩增限制性片段长度多态性分析(RFLP-PCR)技术，对高氡暴露地区53例肺癌患者和72例对照人员进行了代谢酶CYP1A1(MSPⅠ)基因多态性检测，并分析了不同人群中该基因多态性与肺癌发病风险的关系。结果：在氡暴露地区CYP1A1(MSPⅠ) 基因杂合型人群的肺癌发病的OR(优势比)值为1.03(95％可信限 0.468～2.30)。分层分析：有效剂量<50 mSv的人群中CYP1A1(MSPⅠ) 基因杂合型的肺癌发病风险增至4.29倍(95％可信限 0.582～88.2)，年龄在40～59岁人群中CYP1A1(MSPⅠ) 基因杂合型的肺癌发病风险是野生型的1.22倍(95％可信限 0.145～3.65)。结论： CYP1A1(MSPⅠ)基因多态性与肺癌易感性无显著关联，但CYP1A1(MSPⅠ)基因杂合型对观察人群的肺鳞癌发病风险、有效剂量<50 mSv的人群肺癌发病风险、非吸烟人群的肺癌发病风险和40～59岁人群肺癌发病风险均有增高的趋势。

关键词: 氡, CYP1A1, 基因多态性, 肺癌易感性

Abstract: BACKGROUND AND AIM: To assess the role of genetic polymorphisms of metabolic enzyme Cytochrome P450 1A1(CYP1A1) in the risk of developing lung cancer for the people living in high radon-exposed area. MATERIALS AND METHODS: A case-control study was performed with 53 lung cancer patients and 72 frequency-matched controls. The associations between genotypes and risk of developing lung cancer were estimated by odds ratios (ORs) and their 95％ confidence intervals (CIs) calculated by unconditional logistic regression. RESULTS: Risk of developing lung cancer for heterozygous CYP1A1 (MSPⅠ) polymorphism was 1.03-fold (95％CI 0.468－2.28) higher than that for wild type of CYP1A1 (MSPⅠ) polymorphism. Stratified analysis showed that with effective dose<50 mSv the risk of developing lung cancer for heterozygous CYP1A1 (MSPⅠ) polymorphism increased to 4.29-fold (95％CI 0.582－88.2). In people heterozygous for CYP1A1 (MSPⅠ) polymorphism aged between 40 and 59, the risk of developing lung cancer was 1.22-fold higher than that for wild type of CYP1A1 (MSPⅠ) polymorphism. CONCLUSION: The present results indicated genetic polymorphisms of CYP1A1 might increase the risk of developing lung cancer, but the difference was not statistically significant.

Key words: radon, CYP1A1, genetic polymorphisms, lung cancer susceptibility

齐雪松, 夏　英, 孙全富, 尚　兵, 吕慧敏, 程同心, 崔宏星, 冯顺治, 王利平, 王　浩, 孙粉珍. 高氡暴露地区人群中代谢酶CYP1A1基因多态性与肺癌易感性的关系[J]. 癌变·畸变·突变, 2008, 20(1): 11-014.

QI Xue-song, XIA Ying, SUN Quan-fu, SHANG Bing, LU Hui-ming, CHENG Tong-xin, CUI Hong-xing, FENG Shun-zhi, WANG Li-ping, WANG Hao, SUN Fen-zhen. Association between Genetic Polymorphisms of CYP1A1 and Lung Cancer Susceptibility for People Living in High Radon-exposed Area[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2008, 20(1): 11-014.

[1]	陆雪梅, 许铭炎, 刘庭英, 张秋芳, 邓小玲. 潮汕地区汉族人群MTHFR基因rs1801131多态性与非综合征型唇腭裂的相关性研究[J]. 癌变·畸变·突变, 2021, 33(5): 334-337,344.
[2]	李丹, 刘宝英, 余明明, 庄海林, 揭金花, 吴涵梅. NFKBIA基因多态性、饮食习惯及其交互作用与胃癌易感性的关系[J]. 癌变·畸变·突变, 2020, 32(3): 198-202.
[3]	徐石张, 谢敏娟. 儿童原发性激素敏感型肾病综合征与ACE基因多态性关系的meta分析[J]. 癌变·畸变·突变, 2018, 30(6): 447-451.
[4]	高延晓, 田梅, 高刚, 刘建香. 降扎乡高氡温泉周围居民血浆中8-羟基脱氧鸟苷和硫氧还蛋白还原酶水平的研究[J]. 癌变·畸变·突变, 2018, 30(3): 226-229.
[5]	刘春旭, 李小亮, 潘艳, 阮健磊, 高刚, 田梅, 刘建香. 某氡温泉周边居民外周血淋巴细胞中miRNAs的表达[J]. 癌变·畸变·突变, 2015, 27(6): 446-449.
[6]	木妮热·木沙江, 古丽扎热叶·艾库拉, 贺春钰, 木克代斯·拜克提亚尔. 新疆维吾尔族女性乳腺癌与HLA-DRB1基因多态性的关系及临床意义[J]. 癌变·畸变·突变, 2015, 27(5): 366-369.
[7]	刘芡芡, 孙玲玲, 王宏, 吴越, 王如欣, 罗兵, 王云. EB病毒潜伏膜蛋白1基因多态性与NK/T细胞淋巴瘤的相关性[J]. 癌变·畸变·突变, 2015, 27(4): 266-271.
[8]	谈柯宏, 于德财, 张娟, 尹立红, 浦跃朴. KCNQ4和GJB2基因多态性与职业噪声性听力损失的相关性研究[J]. 癌变·畸变·突变, 2015, 27(4): 284-287.
[9]	王兰，朱公建，闵建平，郭红云，杨碎胜，张斌明，胡清荣，杨凯，陈学忠，苏海翔. 甘肃汉族妇女XRCC1和CCNH基因多态性与乳腺癌及乳腺良性肿瘤易感性研究[J]. 癌变·畸变·突变, 2014, 26(4): 292-297.
[10]	黄标通，周新民，龙建平. Toll样受体基因多态与肿瘤易感性的研究进展[J]. 癌变·畸变·突变, 2014, 26(3): 231-238.
[11]	赵真真，石源源，刘颂，王笑峰，罗兵*. Toll样受体基因多态性与EBV感染相关胃癌的易感性[J]. 癌变·畸变·突变, 2014, 26(3): 171-174.
[12]	李君,蒋守芳,陈海燕,刘坤,袁聚祥,牛凤玲,张国志. 环境危险因素和NAT2基因多态性的交互作用与女性乳腺癌的关系[J]. 癌变·畸变·突变, 2013, 25(2): 100-105.
[13]	陈志海,聂继华,武彦文,吴昭昭,张素萍,曹毅,童建. 氡吸入染毒致大鼠相关靶器官的损伤[J]. , 2011, 23(6): 460-464.
[14]	朱茂祥. 放射性核素的健康影响及促排措施[J]. , 2011, 23(6): 468-472.
[15]	陈志海,童建. 氡致肺癌研究进展[J]. , 2011, 23(6): 482-484.

高氡暴露地区人群中代谢酶CYP1A1基因多态性与肺癌易感性的关系

Association between Genetic Polymorphisms of CYP1A1 and Lung Cancer Susceptibility for People Living in High Radon-exposed Area

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价