[1] 张爱华. 表观遗传学:揭示砷中毒机制及改进防治策略的新路径[J]. 中华地方病学杂志,2013,32(1):1-2. [2] Loriot A,De Plaen E,Boon T,et al. Transient down-regulation of DNMT1 methylfransferase leads to activation antd stable hypomethylation of MAGE-A1 in melanoma cells[J]. J Biol Chem,2006,281(15):10118-10126. [3] Raddatz G,Guzzardo PM,Olova N,et al. DNMT2-dependent methylomes lack defined DNA methylation patterns[J].PNAS,2013,110(21):8627-8631. [4] Takayama S,Dhahbi J,Roberts A,et al. Genome methylation in melanogaster is found at specific short motifs and is independent of DNMT2 activity[J]. Genome Res,2014,24(5):821-830. [5] Saito Y,Kanai Y,Sakamoto M,et al. Overexpression of a splice variant of DNA methyltransferase 3b,DNMT3b4,associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis[J]. PNAS,2002,99(15):10060-10065. [6] Roman-Gomez J,Jimenez-Velasco A,Agirre X,et al. Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia[J]. Oncogene,2005,24(48):7213-7223. [7] Ostler K,Davis E,Payne S,et al. Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins[J]. Oncogene,2007,26(38):5553-5563. [8] Zhu JK. Active DNA demethylation mediated by DNA glycosylases[J]. Annu Rev Genet,2009,43(2):143-166. [9] Di Ruscio A,Ebralidze AK,Benoukraf T,et al. DNMT1-interacting RNAs block gene-specific DNA methylation[J]. Nature,2013,503(7476):371-376. [10] Hu JL,Zhou BO,Zhang RR,et al. The N-terminus of histone H3 is required for denovo DNA methylation in chromatin[J]. Proc Natl Acad Sci USA,2009,106(52):22187-22192. [11] Li BZ,Huang Z,Cui QY,et al. Histone tails regulate DNA methylation by allosterically activating de novo methyltransferase[J]. Cell Res,2011,21(8):1172-1181. [12] The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome[J]. Nature,2012,489(7414):57-74. [13] Pogribny IP,Ross SA,Wise C,et al. Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency[J]. Mut Res,2006,593(1):80-87. [14] James SJ,Pogribny IP,Pogribna M,et al. Mechanisms of DNA damage,DNA hypomethylation,and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis[J]. J Nutrit,2003,133(11):3740-3747. [15] Hoflftnann MJ,Schixlz WA. Causes and consequences of DNA hypomethylation in human cancer[J]. Biochem Cell Biol,2005,83(3):296-321. [16] Friso S,Choi SW,Girelli D,et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status[J]. PNAS,2002,99(8):5606-5611. [17] Park IY,Sohn BH,Yu E,et al. Aberrant epigenetic modifications in heaptocarcinogenesis induced by hepatitis B virus X protein[J]. Gastroenterology,2007,132(4):1476-1494. [18] 李静,吴顺华. 砷致DNA甲基化变化与致癌作用的研究进展[J]. 国外医学:地理分册,2014,35(3):247-251. [19] Sadikovic B,Rodenhiser DI. Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells[J]. Toxicol Applied Pharm,2006,216(3):458-468. [20] Pogribny I,Koturbash I,Tryndyak V,et al. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus[J]. Mol Cancer Res,2005,3(10):553-561. [21] Feinberg AP,Vogelstein B. Hypomethylation of ras oncogenes in primary human cancers[J]. Biochem Biophy Res Commun,1983,111(1):47-54. [22] Cheah MS,Wallace CD,Hofnan RM. Hypomethylation of DNA in human cancer cells:a site-specific change in the c-myc oncogene[J]. J Nat Cancer Inst,1984,73(5):1057-1065. [23] Goldstein M,Meller I,Orr-Urtreger A.FGFR1 overexpression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5iCpG island and abnormal expression of the AKT1,NOG,and BMP4 genes[J]. Gene Chromosome Canc,2007,46(11):1028-1038. [24] Roman-Gomez J,Jimenez-Velasco A,Castillejo JA,et al. Promoter hypermethylation of cancer-related genes:a strong independent prognostic factor in acute lymphoblastic leukemia[J]. Blood,2004,104(8):2492-2498. [25] Watanabe M,Ogawa Y,Itoh K,et al. Hypomethylation of CD30 CpG islands with aberrant Jun B expression drives CD30 induction in Hodgkin lymphoma and anaplastic large cell lymphoma[J]. Lab Invest,2007,88(1):48-57. [26] Kim SJ,Kang HS,Chang HL,et al. Promoter hypomethylation of the N-acetyltransferase 1 gene in breast cancer[J]. Oncol Rep,2008,19(3):663-668. [27] Cui H,Onyango P,Brandenburg S,et al. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2[J]. Cancer Res,2002,62(22):6442-6446. [28] Ley TJ,DeSimone J,Noguchi CT,et al. 5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia[J]. Blood,1983,62(2):370-380. [29] Li G,Cuilleron M,Cottier M,et al. The use of MN/CA9 gene expression in identifying malignant solid renal tumors[J]. Eur Urol,2006,49(2):401-405. [30] 张爱华,潘雪莉,夏玉洁,等. p53基因甲基化和突变与燃煤污染型砷中毒关系研究[J]. 中华预防医学杂志,2011,45(5):393-398. [31] Gaudet F,Hodgson JG,Eden A,et al. Induction of tumors in mice by genomic hypomethylation[J]. Science,2003,300(5618):489-492. [32] Ehrlich M. The ICF syndrome,a DNA methyltransferase 3B deficiency and immuno-deficiency disease[J]. Clin Immun,2003,109(1):17-28. [33] Yoshida T,Yamashita S,Takamura-Enya T,et al. Alu and Satαhypomethylation in helicobacter pylori infected gastric mucosae[J]. Int J Cancer,2011,128(1):33-39. [34] Tian F,Tang Z,Song G,et al. Loss of imprinting of IGF2 correlates with hypomethylation of the H19 differentially methylated region in the tumor tissue of colorectal cancer patients[J]. Mol Med Rep,2012,5(6):1536-1540. [35] Scelfo R,Schwienbacher C,Veronese A,et al. Loss of methylation at chromosome llpl5. 5 is common in human adult tumors[J]. Oncogene,2002,21(16):2564-2572. [36] Weber M,Davies JJ,Wittig D,et al. Chromosome wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells[J]. Nat Genet,2005,37(8):853-862. [37] Fraga MF,Herranz M,Espada J,et al. A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors[J]. Cancer Res,2004,64(16):5527-5534. [38] Lin CH,Hsieh SY,Sheen IS,et al. Genome wide hypomethylation in hepatocellular carcino-genesis[J]. Cancer Res,2001,61(10):4238-4243. [39] Wong N,Lam WC,Lai PBS,et al. Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma[J]. Am J Pathol,2001,159(2):465-471. [40] Ting DT,Lipson D,Paul S,et al.Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers[J]. Science,2011,331(6017):593-596. |