谷氨酰胺代谢在机体免疫调控中作用的研究进展

doi:10.3969/j.issn.1004-616x.2023.03.014

摘要/Abstract

摘要： 谷氨酰胺(Gln)是机体内含量最丰富和用途最广泛的氨基酸，对于维持机体健康具有重要意义。研究表明，Gln是一种具有免疫调节特性的非必须氨基酸，可作为淋巴细胞、巨噬细胞和中性粒细胞的“重要燃料”，参与调控此类细胞的增殖、吞噬与炎症过程。正常情况下机体可通过饮食对Gln进行补充，而严重疾病和过度运动时体内Gln过度分解，因含量无法满足需求而导致免疫功能紊乱。本文主要综述了Gln的生物学功能、代谢与机体免疫调控，以及在感染、脓毒症、肿瘤发生中的作用机制等的最新研究进展。

关键词: 谷氨酰胺, 免疫调控, 中性粒细胞, 巨噬细胞, T细胞, 肿瘤

中图分类号:

R994.6

彭洁, 曹猛, 孙慕涵, 李宏伟, 张渤旭, 王钰越, 马加骏, 孔德钦, 刘江正, 于卫华. 谷氨酰胺代谢在机体免疫调控中作用的研究进展[J]. 癌变·畸变·突变, 2023, 35(3): 231-235,239.

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