癌变·畸变·突变 ›› 1999, Vol. 11 ›› Issue (2): 99-101.doi: 10.3969/j.issn.1004-616x.1999.02.012

• 论著 • 上一篇    下一篇

高放射性矿泉水对小鼠微核和精子的影响

吕文戈1  巴 月1  程学敏1  扬建勋1  付润芳2  冯国清2  王希林1  郜金社1   

  1. 1 河南医科大学环境卫生学教研室 郑州 450052  2 河南医科大学药理学教研室 郑州 450052
  • 收稿日期:1998-03-24 修回日期:1998-06-07 出版日期:1999-03-30 发布日期:1999-03-30

THE EFFECTS OF MINERAL WATER WITH HIGH RADIATION ON MICRONUCLEUS AND SPERMATOZOON OF MICE

Lu Wenge1 , Ba Yue1 , Chen Xuemin1 , Yang Jianxun1 , Fu Runfang2 , Feng Guoqing2 , Wang Xilin1 , Gao Jinshe1   

  1. 1 Department of Envi ronmental Heal th , Henan Medical University , Zhengz hou  450052  2 Department of Pharmacology , Henan Medical University , Zhengz hou  450052
  • Received:1998-03-24 Revised:1998-06-07 Online:1999-03-30 Published:1999-03-30

摘要: 选用放射性水平不同的矿泉水喂养实验动物,分别在第50d、100d、150d 时采集相应标本进行微核和精子畸形实验,结果显示:饮用高放射性矿泉水组动物的微核率、精子数量和精子活动率在有些时期同对照组比较表现出显著差异( P < 0. 05) ,提示当矿泉水中的放射性比活度超过一定剂量时可能会对小鼠产生一定的遗传毒性效应。

关键词: 高放射性矿泉水, 微核, 精子

Abstract: Mineral water with high radiation was tested to evaluate it s genetic toxicity. In the experiment the Kunming mice were randomly divided into 3 groups , one group , fed with tap water and the other two with different highly2radiated mineral water. Samples were collected on the 50th day ,100th day ,150th day , respectively. Result s showed that the f requencies of the micronucleus and number of motile sperms of the mice drinking highly-radiated mineral water are significantly different ( P < 0. 05) as compared with those drinking tap water at certain period of time. Thus it suggested that the mineral water with high radiation might possess potential mutagenic effect on the animals.

Key words: High radiation mineral water, micronucleus, Spermatozoon