河南“4.26”60Co源辐射事故受照者细胞遗传学随访观察

doi:10.3969/j.issn.1004-616x.2007.05.017

癌变·畸变·突变 ›› 2007, Vol. 19 ›› Issue (5): 406-408.doi: 10.3969/j.issn.1004-616x.2007.05.017

河南“4.26”60Co源辐射事故受照者细胞遗传学随访观察

韩　林1/ 段国禄2/ 王喜爱1/ 赵阳辉2/ 傅宝华1/ 赵凤玲1/ 吕玉民1,3

(1.河南省职业病防治研究所　郑州　450052；2.洛阳市环境监测站，洛阳　471000; 3.郑州大学公共卫生学院，郑州　450052)

收稿日期:2006-10-08 修回日期:2006-12-13 出版日期:2007-09-30 发布日期:2007-09-30
通讯作者: 吕玉民

Follow up of the Cytogenetics on 6 Victims Exposed to 60Co Radiation Accident in Henan

HAN Lin1，DUAN Guo_lu2，Wang Xi_ai1，ZHAO Yang_hui2，FU Bao_hua1，ZHAO Feng_ling1 ，LU Yu_min1，3,

(1.Henan Institute of Occupational Medicine, Zhengzhou 450052;2.Luoyang Instiurte of Environmental Inspection,Luoyang 471000;3. Public Health College of Zhengzhou University, Zhengzhou 450052，China)

Received:2006-10-08 Revised:2006-12-13 Online:2007-09-30 Published:2007-09-30
Contact: LU Yu_min

摘要/Abstract

摘要： 背景与目的: 对河南“4.26”60Co源辐射事故受照者进行细胞遗传学随访观察。材料与方法：利用微量全血培养法制备外周血淋巴细胞染色体和胞质分裂阻断(CB)微核标本，对河南新乡60Co源辐射事故6例受照者照后1～2年的染色体畸变和CB微核进行分析。结果：受照1～2年后受照者的染色体畸变率已明显下降，受照1年后非稳定性染色体畸变仍占有较大比例(40％～60％)；受照2年后稳定性染色体畸变高于非稳定性染色体畸变，但差异无统计学意义(P>0.05，1例受照者除外，其P<0.01)；受照1～2年后染色体总畸变率与受照剂量间仍有明显的剂量效应关系(r<0.936，P均<0.01)；而受照1～2年后多数受照者的CB微核率已降到正常参考值范围。结论：随着照后时间推移，非稳定性染色体畸变逐渐丢失，稳定性染色体畸变仍保持在较高水平；微核分析不适用于大剂量受照个体远后遗传效应的评价。

关键词: 60Co源辐射事故, 染色体畸变, CB微核, 随访观察

Abstract: BACKGROUND ＆ AIM: Follow up cytogenetic tests was performed on the 6 victims exposed to 60Co radiation accident in Henan. MATERIALS AND METHODS: The samples of chromosome and CB micronucleus were prepared by using cultured whole blood, and analysis of chromosomal aberrations and CB micronuclei were made in the 6 victims exposed to 60Co radiation accident occurred in Xinxiang of Henan 1_2 years after irradiation. RESULTS： The frequencies of chromosomal aberrations in the victims had obviously declined in 1_2 years after irradiation. The proportion of unstable chromosomal aberration was higher in 1 year, and the rate of stable chromosomal aberrations was greater than that of unstable 2 year after irradiation. Frequencies of CB micronuclei in the victims had mostly declined into the background range in 1_2 years after irradiation. CONCLUSION： The results suggested that unstable chromosomal aberrations had gradually resolved, and stable chromosomal aberrations was still the majority as time progressed after irradiation. Late genetic effects of individuals exposed to high_dose irradiation can not be evaluated by analysis of CB micronucleus.

Key words: 60Co radiation accident, chromosomal aberration, CB micronucleus, follow up observation

中图分类号:

Q343.2

韩　林/ 段国禄/ 王喜爱/ 赵阳辉/ 傅宝华/ 赵凤玲/ 吕玉民, . 河南“4.26”60Co源辐射事故受照者细胞遗传学随访观察[J]. 癌变·畸变·突变, 2007, 19(5): 406-408.

HAN Lin, DUAN Guo_lu, Wang Xi_ai, ZHAO Yang_hui, FU Bao_hua, ZHAO Feng_ling , LU Yu_min, . Follow up of the Cytogenetics on 6 Victims Exposed to 60Co Radiation Accident in Henan[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2007, 19(5): 406-408.

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河南“4.26”60Co源辐射事故受照者细胞遗传学随访观察

Follow up of the Cytogenetics on 6 Victims Exposed to 60Co Radiation Accident in Henan

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